Alcohol Consumption Can be a Double-Edged Sword for Chronic Kidney Disease Patients

As a consequence, oxidative stress not only propagates kidney failure, but it also contributes to the progression of chronic heart failure (Pacher et al. 2005) and leads to a vicious cycle in alcohol-induced cardiovascular complications. Hence, we sought to examine the association of alcohol consumption with the change and rapid decline in kidney function over 12 years in a South Korean population-based cohort study. Addressing kidney failure and disease as a result of excessive drinking can also mean receiving alcoholism treatment and counseling.

Studies suggest that several mechanisms produce ROS in alcohol-damaged organs, including the liver (Cederbaum et al. 2009), heart (Tan et al. 2012; Varga et al. 2015), and kidney (Latchoumycandane et al. 2015). CYP2E1 is of particular interest when thinking about potential mechanisms for alcohol-related kidney damage. The body mainly metabolizes alcohol using the enzyme alcohol dehydrogenase, which is expressed primarily in the liver. However, during chronic ethanol consumption, the body also uses CYP2E1 in the liver as well as the kidneys. Interestingly, studies find that CYP2E1 induction is much more robust in the kidneys compared with the liver (Roberts et al. 1994; Zerilli et al. 1995).

Cited by other articles

Kidneys are essential to keeping the body healthy and free of harmful substances such as alcohol. The kidneys also maintain the proper balance of fluid and electrolytes. These hormones help stimulate red blood cell growth and regulate blood pressure.

1. Oxidative stress occurs when the body cannot detoxify free radicals as fast as they are being produced, and it is pivotal in triggering alcohol-related tissue injury.
2. However, more research is needed into the link between alcohol use and kidney injury.
3. Studies suggest that ethanol consumption may increase renal expression of other potential sources of free radicals involving a family of enzymes called nitric oxide synthases (Tirapelli et al. 2012).
4. Your doctor may prescribe kidney medication or recommend programs in your area to help you.

According to Dr. Bobart, there’s no research to suggest a link between alcohol and kidney pain. Certain medical conditions and other factors may increase the risk of interactions with Veozah. Before you take this drug, be sure to talk with your doctor about your health history.

How Alcohol Affects Kidney Health Long Term

In a small pilot study, he and colleagues found that intestinal microbiota transplantation (IMT) appears to be safe and effective for these patients. Doctors typically won’t prescribe Veozah if you how to smoke moon rocks have a severe kidney problem, including end stage kidney disease. Having a severe kidney problem can affect how well your body gets rid of Veozah. This can lead to a high level of Veozah in your system, raising your risk of Veozah side effects.

Treatments for acute kidney injury

In terms of liver-related outcomes, some patients developed hepatic encephalopathy (11.8% in fixed dose vs 6.3% in tapering dose) and acute variceal bleed (3.1% in each group), as well as acute kidney injury (26.8% in fixed dose vs 18.9% in tapering dose). These are signs that the kidneys are not working as they should, and they can be symptoms of acute kidney injury due to a high alcohol consumption. If you experience kidney pain after drinking alcohol, it’s essential that you pay attention to your body and what it’s telling you. You may need to take a complete break from alcohol for a set amount of time or reduce the amount of alcohol you consume.

Since women, with a lower proportion of body water, have a smaller distribution volume for alcohol, they are more likely to have a higher concentration of alcohol in the blood than men. Moreover, women with a lower activity of gastric alcohol dehydrogenase have lower gastric first-pass metabolism of alcohol, which also leads to a higher concentration of alcohol than in men 92. Since women have a higher blood concentration of alcohol, they may be more sensitive to alcohol than men 3,50,90. At the same time, the difference in the actual amounts of alcohol consumption 79 between men and women causes this sex difference. Men generally drink more than women, and men have higher rates of alcoholism than women.

Several epidemiological studies have shown that mild alcohol consumption benefits cardiovascular health (Coate 1993; Kannel and Ellison 1996) by reducing the risk of coronary heart disease (Mukamal et al. 2006). In contrast, heavy drinking leads to the development of nonischemic dilated cardiomyopathy (Klatsky 2007) and significantly increases the risk of sudden cardiac death (Hookana et al. 2011). Due to the metabolism of ethanol, significant amounts of acetate are produced and subsequently incorporated into acetyl-coenzyme-A, a molecule that participates in metabolism of proteins, lipids, and carbohydrates. Protein acetylation—adding an acetyl group to a protein—is integral to regulating processes controlled by mitochondria, including fatty acid metabolism and antioxidant defense (Choudhary et al. 2014).